Abbreviated Curriculum Vitae
Research Interests
The structure and dynamics of protein-signalling systems: systems biology, protein networks, system modeling, post-translational protein modifications, cellular signaling pathways, epistasis, molecular evolution, natural computing
Professional Experience
- 2019-present: Research Fellow University of Exeter Exeter, UK
- 2013–2018: ESPOD Fellow EMBL-European Bioinformatics Institute and Wellcome Trust Sanger Institute Hinxton, UK
- 2004–2007: Research Technician Northwestern University Evanston, IL, USA
Education
- PhD, Biomedicine Institute of Evolutionary Biology (UPF-CSIC) Pompeu Fabra University, Barcelona, ES (2013)
- MSc, Biology Leiden University, Leiden, NL (2009)
- BSc, Computer Science and Software Engineering Rose-Hulman Institute of Technology, Terre Haute, IN, USA (2004)
Peer-Reviewed Publications
Invergo BM. 2021. Accurate, high-coverage assignment of in vivo protein kinases to phosphosites from in vitro phosphoproteomic specificity data. bioRxiv. 2021.08.31.458376. Preprint.
Jeffery N, Chambers D, Invergo BM, Ames RM, Harries LW. 2021. Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD. Cell Biosci.. 11(1): 144.
Goode O, Smith A, Zarkan A, Cama J, Invergo BM, Belgami D, Caño-Muñiz S, Metz J, O'Neill P, Jeffries A, Norville IH, David J, Summers D, Pagliara S. 2021. Persister Escherichia coli cells have a lower intracellular pH than susceptible cells but maintain their pH in response to antibiotic treatment. 12(4): e0090921.
More KR, Kaur I, Gianetto QG, Invergo BM, CHaze T, Jain R, Huon C, Gutenbrunner P, Weisser H, Matondo M, Choudhary JS, Langsley G, Singh S, Chitnis CE. 2020. Phosphorylation-dependent assembly of a 14-3-3 mediated signaling complex during red blood cell invasion by Plasmodium falciparum merozoites. mBio. 11(4): e01287-20.
Invergo BM, Petursson B, Akhtar N, Bradley D, Giudice G, Hijazi M, Cutillas P, Petsalaki E, Beltrao P. 2020. Prediction of signed protein kinase regulatory circuits. Cell Systems. 10(5): 384-396.e9.
Invergo BM, Beltrao P. 2018. Reconstructing phosphorylation signalling networks from quantitative phosphoproteomic data. Essays in Biochemistry 62(4):525-534.
Invergo BM, Brochet M, Yu L, Choudhary J, Beltrao P, Billker O. 2017. Sub-minute phosphoregulation of cell cycle systems during Plasmodium gamete formation. Cell Reports 21(7):2017-2029.
Fernández-Sampedro MA, Invergo BM, Ramon E, Bertranpetit J, Garriga P. 2016. Functional role of positively selected amino acid substitutions in mammalian rhodopsin evolution. Scientific Reports 6:21570.
Invergo BM, Montanucci L, Bertranpetit J. 2015. Dynamic sensitivity and nonlinear interactions influence the system-level evolutionary patterns of phototransduction proteins. Proceedings of the Royal Society B: Biological Sciences. 282(1820):20152215.
Hodson N, Invergo BM, Rayner JC, Choudhary JS. 2015. Palmitoylation and palmitoyl-transferases in Plasmodium parasites. Biochem. Soc. Trans. 43(2):240-245.
Invergo BM, Dell'Orco D, Montanucci L, Koch KW, Bertranpetit J. 2014. A comprehensive model of the phototransduction cascade in mouse rod cells. Molecular BioSystems 10(6):1481-1489.
Colombo M, Laayouni H, Invergo BM, Bertranpetit J, Montanucci L. 2013. Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes. Evolution 68(2):605-613.
Invergo BM, Montanucci L, Koch KW, Bertranpetit J, Dell'Orco D. 2013. Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling. Cell Communication and Signaling 11(1):36.
Invergo BM, Montanucci L, Laayouni H, Bertranpetit J. 2013. A system-level, molecular evolutionary analysis of mammalian phototransduction. BMC Evolutionary Biology 13:52.
Talevich E, Invergo BM, Cock PJ, Chapman BA. 2012. Bio.Phylo: a unified toolkit for processing, analyzing and visualizing phylogenetic trees in Biopython. BMC Bioinformatics 13:209.
Oostra V, de Jong MA, Invergo BM, Kesbeke F, Wende F, Brakefield PM, Zwaan BJ. 2011. Translating environmental gradients into discontinuous reaction norms via hormone signalling in a polyphenic butterfly. Proceedings of the Royal Society B: Biological Sciences 278(1706):789-97.
Maddox DM, Vessey KA, Yarbrough GL, Invergo BM, Cantrell DR, Inayat S, Balannik V, Hicks WL, Hawes NL, Byers S, Smith RS, Hurd R, Howell D, Gregg RG, Chang B, Naggert JK, Troy JB, Pinto LH, Nishina PM, McCall MA. 2008. Allelic variance between GRM6 mutants, Grm6nob3 and Grm6nob4 results in differences in retinal ganglion cell visual responses. The Journal of Physiology 586:4409-24.
Pinto LH, Invergo B, Shimomura K, Takahashi JS, Troy JB. 2007. Interpretation of the mouse electroretinogram. Documenta Opthalmologica 115(3):127-36.
Pinto LH, Vitaterna MH, Shimomura K, Siepka SM, Balannik V, McDearmon EL, Omura C, Omura C, Lumayag S, Invergo BM, Glawe B, Cantrell DR, Inayat S, Olvera MA, Vessey KA, McCall MA, Maddox D, Morgans CW, Young B, Pletcher MT, Mullins RF, Troy JB, Takahashi JS. 2007. Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse. Visual Neuroscience 24(1):111-23.
Pinto LH, Vitaterna MH, Shimomura K, Siepka SM, McDearmon EL, Fenner D, Lumayag SL, Omura C, Andrews AW, Baker M, Invergo BM, Olvera MA, Heffron E, Mullins RF, Sheffield VC, Stone EM, Takahashi JS. 2005. Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse. Visual Neuroscience 22(5):619-29.
Other Publications
- Dall’Olio GM, Marino J, Schubert M, Keys KL, Stefan MI, Gillespie CS, Poulain P, et al. 2011. Ten simple rules for getting help from online scientific communities. PLoS Computational Biology 7(9):e1002202.